In the spring of 1957, Ferrari made a further effort on the 12-cylinder engine intended for sports cars, bringing the total displacement to 4023cc. The car that adopted this engine was called 335S, alongside the 315S and 290MM. The 335S showed its full potential at the 1957 Mille Miglia, even if the victory went to Piero Taruffi's 315S. The 335S, however, secured Ferrari the Sport World Championship that year, with a double win at the Venezuelan GP in Caracas. The career of the 335S continued also in 1958, when the official cars received a modified bodywork that was inspired by the lines of the new 250 TR.
The Ferrari 315S chassis 0646, born as 290S, made its racing debut at the 1000km of Buenos Aires in 1957. In March of the same year it took part in the 12 Hours of Sebring in Florida with Luigi Musso and Alfonso De Portago, with the engine updated to the specifications 315S, finishing seventh overall and fifth in the 5-litre Sport class. For the Mille Miglia the engine was updated to the 335S type: with Alfonso De Portago and Edmund Nelson the car was the protagonist of the Guidizzolo disaster, which put an end to the history of the Mille Miglia.