After the rather disappointing results of the A211, which was an A210 adapted to the 3-liter V6 engine, the Alpine decided to build a completely new car to house the V6. The A220, completed in 1968, had a multitubular structure that included two large side fuel tanks, while the bodywork allowed for quick interventions with large removable parts front and back. However, the A220 experienced a difficult set-up. Four A220s entered the 1968 24 Hours of Le Mans, along with five A210s with 1000, 1300, 1500cc engines. The best of the A220s will finish in eighth place. The following year, out of 8 Alpines entered, only one finished the race. Considering also the growing strength of the Matra, Jean Rédélé made the wise decision to abandon the prototype sports to concentrate on rallies with the A110.